AMERICAN THORACIC SOCIETY DOCUMENTS An Official American Thoracic Society Statement: Diagnosis and Management of Beryllium Sensitivity and Chronic Beryllium Disease Executive Summary
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چکیده
Main Results: The beryllium lymphocyte proliferation test is the cornerstone of bothmedical surveillance and the diagnosis of BeS and CBD.A confirmed abnormal beryllium lymphocyte proliferation test without evidence of lung disease is diagnostic of BeS. BeS with evidence of a granulomatous inflammatory response in the lung is diagnostic of CBD. The determinants of progression from BeS to CBDareuncertain, but higher exposures and the presence of a genetic variant in the HLA-DP b chain appear to increase the risk. Periodic evaluation of affected individuals can detect disease progression (from BeS to CBD, or from mild CBD to more severe CBD). Corticosteroid therapy is typically administered when a patient with CBD exhibits evidence of significant lung function abnormality or decline.
منابع مشابه
An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease.
RATIONALE Beryllium continues to have a wide range of industrial applications. Exposure to beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). OBJECTIVES The purpose of this statement is to increase awareness and knowledge about beryllium exposure, BeS, and CBD. METHODS Evidence was identified by a search of MEDLINE. The committee then summarized the evidence, dre...
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